Open science and modified funding lotteries can impede the natural selection of bad science.

Assessing scientists using exploitable metrics can lead to the degradation of research methods even without any strategic behaviour on the part of individuals, via 'the natural selection of bad science.' Institutional incentives to maximize metrics like publication quantity and impact drive this dynamic. Removing these incentives is necessary, but institutional change is slow. However, recent developments suggest possible solutions with more rapid onsets. These include what we call open science improvements, which can reduce publication bias and improve the efficacy of peer review. In addition, there have been increasing calls for funders to move away from prestige- or innovation-based approaches in favour of lotteries. We investigated whether such changes are likely to improve the reproducibility of science even in the presence of persistent incentives for publication quantity through computational modelling. We found that modified lotteries, which allocate funding randomly among proposals that pass a threshold for methodological rigour, effectively reduce the rate of false discoveries, particularly when paired with open science improvements that increase the publication of negative results and improve the quality of peer review. In the absence of funding that targets rigour, open science improvements can still reduce false discoveries in the published literature but are less likely to improve the overall culture of research practices that underlie those publications

An investigation into the psychometric properties of the CORE-OM in patients with eating disorders

Aim: The current study aimed to explore the psychometric properties of the CORE‐OM (Clinical Outcomes in Routine Evaluation – Outcome Measure) when used in an eating disorder sample. Method: The CORE‐OM was administered at assessment to 360 individuals referred to an eating disorders service. Principal component analysis was conducted to look at the psychometric structure of the CORE‐OM, and psychometric properties were investigated using analyses of reliability and validity. Results: Analyses of the psychometric structure suggested a three‐component solution reflecting negatively worded, positively worded and risk items. The CORE‐OM showed good acceptability, acceptable internal and test‐retest reliabilities, as well as good convergent and known groups validity. Conclusions: The results of the current study support the CORE‐OM as a reliable and valid measure for assessing psychological distress in eating disorders

LEADING INDICATORS FOR REGIONAL COTTON RESPONSE: STRUCTURAL AND TIME SERIES MODELING RESULTS

Resurging southeastern cotton production compels better cotton acreage forecasts for planning seed, chemical, and other input requirements. Structural models describe leading acreage response indicators, and forecasts are compared time-series models. Cotton price, loan rate, deficiency payments, lagged corn acreage, the PIK program, and previous cotton yield significantly influence response.Crop Production/Industries,

LEADING INDICATORS OF REGIONAL COTTON ACREAGE RESPONSE: STRUCTURAL AND TIME SERIES MODELING RESULTS

Resurgent cotton production compels better acreage forecasts for planning seed, chemical, and other input requirements. Structural models describe leading acreage response indicators, and forecasts are compared to time-series models. Cotton price, loan rate, deficiency payments, lagged corn acreage, the PIK program, and previous cotton yield significantly influence cotton acreage response.resurgent cotton production, cotton acreage, Crop Production/Industries,

Active waiting list management: potential usefulness in a community eating disorders service

We explored the usefulness of an initiative for managing a treatment waiting list in a community eating disorders service. We sent 108 patients awaiting treatment an opt-in letter and, if necessary, a reminder 3 weeks later. Those who opted in were compared with those who did not. Of those receiving the letter, 67.6% opted in and did not differ significantly from those who opted out on measures of eating disorder pathology and general functioning. However, they had waited less time. Opt-in letters may help to identify those who no longer want to access services, thereby allowing resources to be directed towards those who still want treatment

Dense gas and HII regions in the starburst galaxy NGC 253

The energetic activity in the nuclear barred region of NGC 253 is attributable to a burst of star formation. NGC 253 is in many ways a twin of the prototypical starburst galaxy M82; the strong non-thermal radio continuum, high far-infrared luminosity, and bright molecular emission of the central 1 Kpc parallel the morphology of the M82 starburst. Furthermore, the filamentary low ionization optical emission and extended x ray emission along the minor axis in NGC 253 is similar to a scaled down version of the well developed galactic bipolar wind in M82. The infrared luminosity of NGC 253, 3(exp 10) solar luminosity, is comparable to M82 but is emitted from a smaller region (Telesco and Harper 1980). This suggests that the NGC 253 starburst may be more intense and at an earlier evolutionary stage than M82. However, the presence of a non-stellar AGN in NGC 253 may complicate the comparison (Turner and Ho, 1985). Researchers used the Hat Creek millimeter interferometer to map emission from the J = 1 to 0 transitions of HCN and HCO(+) as well as 3 mm continuum emission, toward the nuclear region of NGC 253. The HCO(+) and continuum observations are sensitive to spatial scales from 6 to 45 seconds. The 2 minute field of view comfortably includes the entire starburst region (about 40 seconds; 650 pc). Because the longer baseline HCN observations are not yet complete, they are only sensitive to spatial scales from 15 to 45 seconds

Wind-Tunnel Investigation of Perforated Split Flaps for Use as Dive Brakes on a Tapered NACA 23012 Airfoil

Aerodynamic characteristics of a tapered NACA 23012 airfoil with single and double perforated split flaps have been determined in the NACA 7- by 10-foot wind tunnel. Dynamic pressure surveys were made behind the airfoil at the approximate location of the tail in order to determine the extent and location of the wake for several of the flap arrangements. In addition, computations have been made of an application of perforated double split flaps for use as fighter brakes. The results indicated that single or double perforated split flaps may be used to obtain satisfactory dive control without undue buffeting effects and that single or double perforated split flaps may also be used as fighter brakes. The perforated split flaps had approximately the same effects on the aerodynamic and wake characteristics of the tapered airfoil as on a comparable rectangular airfoil

Robustness promotes evolvability of thermotolerance in an RNA virus

<p>Abstract</p> <p>Background</p> <p>The ability for an evolving population to adapt to a novel environment is achieved through a balance of robustness and evolvability. Robustness is the invariance of phenotype in the face of perturbation and evolvability is the capacity to adapt in response to selection. Genetic robustness has been posited, depending on the underlying mechanism, to either decrease the efficacy of selection, or increase the possibility of future adaptation. However, the true effect of genetic robustness on evolvability in biological systems remains uncertain.</p> <p>Results</p> <p>Here we demonstrate that genetic robustness increases evolvability of thermotolerance in laboratory populations of the RNA virus φ6. We observed that populations founded by robust clones evolved greater resistance to heat shock, relative to populations founded by brittle (less-robust) clones. Thus, we provide empirical evidence for the idea that robustness can promote evolvability in this environment, and further suggest that evolvability can arise indirectly via selection for robustness, rather than through direct selective action.</p> <p>Conclusion</p> <p>Our data imply that greater tolerance of mutational change is associated with virus adaptability in a new niche, a finding generally relevant to evolutionary biology, and informative for elucidating how viruses might evolve to emerge in new habitats and/or overcome novel therapies.</p